Pharmacokinetic Study of Non–steroidal Anti–inflammatory Drugs in Wildlife Rehabilitation Birds
DOI:
https://doi.org/10.53607/wrb.v24.197Abstract
While the use of non–steroidal anti–inflammatory drugs (NSAIDs) is common in many veterinary practices, there is little information on the efficacy and appropriate dosage levels in avian species. This study examined the pharmacokinetics of one NSAID, meloxicam, given orally to wild birds undergoing rehabilitation. Meloxicam was administered at 1 mg/kg. The primary species studied was Canada goose, but red–tailed hawk was included as a comparison between these species of birds. After administration of meloxicam, blood samples were taken at a series of time intervals to determine the concentration of drug in the serum over time. The study concluded that 1 mg/kg is an appropriate dosage but should be administered twice daily instead of once a day due to the elimination rate in Canada geese. These results suggest that red–tailed hawks absorb and eliminate meloxicam at a different rate, but additional studies are needed to confirm this finding.
Downloads
References
Baert, K., and P. De Backer. 2003. Comparative pharmacokinetics of three non–steroidal anti–inflammatory drugs in five bird species. Comparative Biochemistry and Physiology. 134 (Pt C):25–33.
Baert, K., and P. De Backer. 2002. Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics. 25:449–453.
Boehringer Ingelheim Vetmedica, Inc., and Merial. March 2003. Client Information for Metacam (meloxicam) 1.5 mg/ml Oral Suspension. Drug Insert Pamphlet.
Livingston, A. 2000. Mechanism of action of non–steroidal anti–inflammatory drugs.
Veterinary Clinics of North America, Small Animal Practice. 30:773–781.
Machin, K. L., L. A. Tellier, S. Lair, and A. Livingston. 2001. Pharmacodynamics of flunixin and ketoprogen in mallard ducks (Anas platyrhynchos). Journal of Zoo and Wildlife Medicine. 32(2):222–229.
Pain Management in Clinical Practice Round Table Discussion. 1998. Journal of Avian Medicine and Surgery. 12(4):276–278.
Paul–Murphy, J., and J. W. Ludders. 2001. Avian Analgesia. Veterinary Clinics of North America, Exotic Animal Practice. 4:35–45.
Rudik–Miksa, I., M. R. Cummings, and R. H. Poppenga. 2005. Multi–residue determination of anti–inflammatory analgesics in sera by liquid chromatography–mass spectrometry. Journal of Analytical Toxicology. 29(2):95–104.
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2006 Sara Caruso DVM, Erica A. Miller DVM, Robert Poppenga DVM, PhD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The copyright for articles in this journal is retained by the author(s), with first publication rights granted to the Wildlife Rehabilitation Bulletin and NWRA. Articles published as open-access in this journal are free to use and share with proper attribution in educational and other non-commercial purposes. To obtain reprint permission for articles that are not open access, please contact the journal editor.