Case report: disseminated Staphylococcus aureus infections in two infant desert cottontail rabbits (Sylvilagus audubonii)
DOI:
https://doi.org/10.53607/wrb.v42.273Keywords:
Disseminated infection, rabbit diseases, Wildlife rehabilitation, abscesses, trimethoprim-sulfamethoxazoleAbstract
Staphylococcus aureus is a frequent pathogen in mammals, including rabbits. It can cause suppurative inflammation with a variety of clinical presentations, sometimes resulting in high morbidity and mortality. Outbreaks have been reported in both domestic European rabbits (Oryctolagus cuniculus), and in cottontail rabbits (Sylvilagus spp.). The Colorado Wild Rabbit Foundation recently identified two cases of disseminated S. aureus infections in sibling infant desert cottontail rabbits (S. audubonii) that were presented for rehabilitation. This case report describes the course of the disease, attempted treatment, and pathology findings. Culture and sensitivity tests indicated susceptibility of the pathogen to all antibiotics tested, including trimethoprim-sulfamethoxazole (TMP-SMZ). However, both cases resulted in disseminated spread, against which TMP-SMZ was ineffective. Cottontail rabbit rehabilitators should be aware of the potentially subtle clinical signs, the possibility of outbreaks within a facility, and the difficulties in treating this disease.
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Attili A.-R., Nebbia P., Bellato A., Galosi L., Papeschi C., Rossi G., Linardi M., Fileni E., Cuteri V., Chiesa F. & Robino P. 2020. The effect of age and sampling site on the outcome of Staphylococcus aureus infection in a rabbit (Oryctolagus cuniculus) farm in Italy. Animals 10(5), 774. doi: 10.3390/ani10050774
Barthold S.W., Griffey S.M. & Percy D.H. (eds.) 2016. Rabbit. In Pathology of laboratory rodents and rabbits. 4th ed. Pp. 285–286. Hoboken, NJ: Wiley-Blackwell. doi: 10.1002/9781118924051.ch06
Budde J.A. & McCluskey D.M. 2023. Sulfa-/Trimethoprim. In Plumb’s veterinary drug handbook. 10th ed. P. 1193. Hoboken, NJ: Wiley-Blackwell.
CDC. 2019. Deadly Staph infections still threaten the U.S. Accessed on the internet at https://archive.cdc.gov/#/details?url=https://www.cdc.gov/media/releases/2019/p0305-deadly-staph-infections.html on 9 January 2024.
Cheung G.Y.C., Bae J.S. & Otto M. 2021. Pathogenicity and virulence of Staphylococcus aureus. Virulence 12(1), 547–569. doi: 10.1080/21505594.2021.1878688
Corpa J., Hermans K. & Haesebrouck F. 2009. Main pathologies associated with Staphylococcus aureus infections in rabbits: a review. World Rabbit Science 17, 115–125. doi: 10.4995/wrs.2009.651
de Go´rgolas M., Aviles P., Verdejo C. & Fernandez Guerrero M.L. 1995. Treatment of experimental endocarditis due to methicillin-susceptible or methicillin-resistant Staphylococcus aureus with trimethoprim-sulfamethoxazole and antibiotics that inhibit cell wall synthesis. Antimicrobial Agents and Chemotherapy 39, 953–957. doi: 10.1128/AAC.39.4.953
Espinosa J., Ferreras M.C., Benavides J., Cuesta N., Pérez C., García Iglesias M.J., García Marín J.F. & Pérez V. 2020. Causes of mortality and disease in rabbits and hares: a retrospective study. Animals 10(1), 158. doi: 10.3390/ani10010158
Ferreira A., Monteiro J.M. & Vieira-Pinto M. 2014. The importance of subcutaneous abscess infection by Pasteurella spp. and Staphylococcus aureus as a cause of meat condemnation in slaughtered commercial rabbits. World Rabbit Science 22(4), 311–317. doi: 10.4995/wrs.2014.2238
Fisher P. & Graham J. 2018. Antimicrobial agents used in rabbits. In J.W. Carpenter (ed.): Exotic animal formulary. 5th ed. Pp. 500–502. St. Louis, MO: Elsevier.
Goldstein E.J.C. & Proctor R.A. 2008. Role of folate antagonists in the treatment of methicillin-resistant Staphylococcus aureus infection. Clinical Infectious Diseases 46(4), 584–593. doi: 10.1086/525536
Hermans K., De Herdt P., Devriese L.A., Hendrickx W., Godard C. & Haesebrouck F. 1999. Colonization of rabbits with Staphylococcus aureus in flocks with and without chronic staphylococcosis. Veterinary Microbiology 67(1), 37–46. doi: 10.1016/S0378-1135(99)00028-0
Jangsangthong A., Suriyakhun N., Tunyong W., Kong-Ngoen T., Santajit S., Indrawattana N. & Buranasinsup S. 2022. Occurrence of antimicrobial resistance and antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus isolated from healthy rabbits, Veterinary World 15(11), 2699–2704. doi: 10.14202/vetworld.2022.2699-2704
Markey B.K., Leonard F.C., Archambault M., Cullinane A. & Maguire D. 2013. Staphylococcus species. In Clinical veterinary microbiology, 2nd ed. P. 112. Edinburgh: Elsevier.
McCoy R.H. & Steenbergen F. 1969. Staphylococcus epizootic in western Oregon cottontails. Bulletin of the Wildlife Disease Association 5(1), 11. doi: 10.7589/0090-3558-5.1.11
Miller E.A., Goodman M. & Cox S., (eds.) 2017. Sulfamethoxazole (SMZ)/Trimethoprim (TMP). In NWRA Wildlife Formulary. 4th ed. P. 121. St. Cloud, MN: The National Wildlife Rehabilitators Association.
Ranzani O.T., Motos A., Chiurazzi C., Ceccato A., Rinaudo M., Bassi G.L., Ferrer M. & Torres A. 2020. Diagnostic accuracy of gram staining when predicting staphylococcal hospital-acquired pneumonia and ventilator-associated pneumonia: a systematic review and meta-analysis. Clinical Microbiology and Infection 26(11), 1456–1463. doi: 10.1016/j.cmi.2020.08.015
Schott R. 2017. Extra-label drug use in wildlife rehabilitation medicine. Wildlife Rehabilitation Bulletin 35(2), 33–36. doi: 10.53607/wrb.v35.20
Spaulding A.R., Satterwhite E.A., Lin Y.C., Chuang-Smith O.N., Frank K.L., Merriman J.A., Schaefers M.M., Yarwood J.M., Peterson M.L. & Schlievert P.M. 2012. Comparison of Staphylococcus aureus strains for ability to cause infective endocarditis and lethal sepsis in rabbits. Frontiers in Cellular and Infection Microbiology 2, 18. doi: 10.3389/fcimb.2012.00018
Stewart G.C. 2022. Staphylococcus. In D.S. McVey et al. (eds.): Veterinary microbiology. 4th ed. Pp. 231–239. Hoboken, NJ: Wiley-Blackwell. doi: 10.1002/9781119650836.ch25
Varga Smith M. 2023a. Infectious diseases of domestic rabbits. In Textbook of rabbit medicine. 3rd ed. Pp. 352–353. Edinburgh: Elsevier.
Varga Smith M. 2023b. Abscesses. In Textbook of rabbit medicine. 3rd ed. Pp. 224–225. Edinburgh: Elsevier.
Varga Smith M. 2023c. Therapeutics. In Textbook of rabbit medicine. 3rd ed. Pp. 100–137. Edinburgh: Elsevier.
Wardyn S., Kauffman L. & Smith T. 2012. Methicillin-resistant Staphylococcus aureus in Central Iowa Wildlife. Journal of Wildlife Diseases 48, 1069–1073. doi: 10.7589/2011-10-295
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