Case report: disseminated Staphylococcus aureus infections in two infant desert cottontail rabbits (Sylvilagus audubonii)

Authors

  • Gabriele C. Paul Colorado Wild Rabbit Foundation, Erie, CO, USA
  • Daniel G. Friend Colorado Wild Rabbit Foundation, Erie, CO, USA

DOI:

https://doi.org/10.53607/wrb.v42.273

Keywords:

Disseminated infection, rabbit diseases, Wildlife rehabilitation, abscesses, trimethoprim-sulfamethoxazole

Abstract

Staphylococcus aureus is a frequent pathogen in mammals, including rabbits. It can cause suppurative inflammation with a variety of clinical presentations, sometimes resulting in high morbidity and mortality. Outbreaks have been reported in both domestic European rabbits (Oryctolagus cuniculus), and in cottontail rabbits (Sylvilagus spp.). The Colorado Wild Rabbit Foundation recently identified two cases of disseminated S. aureus infections in sibling infant desert cottontail rabbits (S. audubonii) that were presented for rehabilitation. This case report describes the course of the disease, attempted treatment, and pathology findings. Culture and sensitivity tests indicated susceptibility of the pathogen to all antibiotics tested, including trimethoprim-sulfamethoxazole (TMP-SMZ). However, both cases resulted in disseminated spread, against which TMP-SMZ was ineffective. Cottontail rabbit rehabilitators should be aware of the potentially subtle clinical signs, the possibility of outbreaks within a facility, and the difficulties in treating this disease.

Downloads

Download data is not yet available.

Author Biographies

Gabriele C. Paul, Colorado Wild Rabbit Foundation, Erie, CO, USA

Gabriele C. Paul has been involved in wildlife rehabilitation since 2007, and has focused exclusively on lagomorph rehabilitation since 2013. She is the co-founder and Director of the Colorado Wild Rabbit Foundation. Gabriele has a master’s degree in biology from the University of Colorado and is a Certified Wildlife Rehabilitator (CWR). She is licensed by the state of Colorado for the rehabilitation of small mammals.

Daniel G. Friend, Colorado Wild Rabbit Foundation, Erie, CO, USA

Daniel G. Friend has been involved in lagomorph rehabilitation since 2010, and was a founding Director of the Colorado Wild Rabbit Foundation in 2013, in which he maintains an active role. He is a retired research physicist (Cornell University, AB and University of Colorado, PhD) and continues active leadership roles in several domestic and international physics-focused organizations.

References

Attili A.-R., Nebbia P., Bellato A., Galosi L., Papeschi C., Rossi G., Linardi M., Fileni E., Cuteri V., Chiesa F. & Robino P. 2020. The effect of age and sampling site on the outcome of Staphylococcus aureus infection in a rabbit (Oryctolagus cuniculus) farm in Italy. Animals 10(5), 774. doi: 10.3390/ani10050774

Barthold S.W., Griffey S.M. & Percy D.H. (eds.) 2016. Rabbit. In Pathology of laboratory rodents and rabbits. 4th ed. Pp. 285–286. Hoboken, NJ: Wiley-Blackwell. doi: 10.1002/9781118924051.ch06

Budde J.A. & McCluskey D.M. 2023. Sulfa-/Trimethoprim. In Plumb’s veterinary drug handbook. 10th ed. P. 1193. Hoboken, NJ: Wiley-Blackwell.

CDC. 2019. Deadly Staph infections still threaten the U.S. Accessed on the internet at https://archive.cdc.gov/#/details?url=https://www.cdc.gov/media/releases/2019/p0305-deadly-staph-infections.html on 9 January 2024.

Cheung G.Y.C., Bae J.S. & Otto M. 2021. Pathogenicity and virulence of Staphylococcus aureus. Virulence 12(1), 547–569. doi: 10.1080/21505594.2021.1878688

Corpa J., Hermans K. & Haesebrouck F. 2009. Main pathologies associated with Staphylococcus aureus infections in rabbits: a review. World Rabbit Science 17, 115–125. doi: 10.4995/wrs.2009.651

de Go´rgolas M., Aviles P., Verdejo C. & Fernandez Guerrero M.L. 1995. Treatment of experimental endocarditis due to methicillin-susceptible or methicillin-resistant Staphylococcus aureus with trimethoprim-sulfamethoxazole and antibiotics that inhibit cell wall synthesis. Antimicrobial Agents and Chemotherapy 39, 953–957. doi: 10.1128/AAC.39.4.953

Espinosa J., Ferreras M.C., Benavides J., Cuesta N., Pérez C., García Iglesias M.J., García Marín J.F. & Pérez V. 2020. Causes of mortality and disease in rabbits and hares: a retrospective study. Animals 10(1), 158. doi: 10.3390/ani10010158

Ferreira A., Monteiro J.M. & Vieira-Pinto M. 2014. The importance of subcutaneous abscess infection by Pasteurella spp. and Staphylococcus aureus as a cause of meat condemnation in slaughtered commercial rabbits. World Rabbit Science 22(4), 311–317. doi: 10.4995/wrs.2014.2238

Fisher P. & Graham J. 2018. Antimicrobial agents used in rabbits. In J.W. Carpenter (ed.): Exotic animal formulary. 5th ed. Pp. 500–502. St. Louis, MO: Elsevier.

Goldstein E.J.C. & Proctor R.A. 2008. Role of folate antagonists in the treatment of methicillin-resistant Staphylococcus aureus infection. Clinical Infectious Diseases 46(4), 584–593. doi: 10.1086/525536

Hermans K., De Herdt P., Devriese L.A., Hendrickx W., Godard C. & Haesebrouck F. 1999. Colonization of rabbits with Staphylococcus aureus in flocks with and without chronic staphylococcosis. Veterinary Microbiology 67(1), 37–46. doi: 10.1016/S0378-1135(99)00028-0

Jangsangthong A., Suriyakhun N., Tunyong W., Kong-Ngoen T., Santajit S., Indrawattana N. & Buranasinsup S. 2022. Occurrence of antimicrobial resistance and antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus isolated from healthy rabbits, Veterinary World 15(11), 2699–2704. doi: 10.14202/vetworld.2022.2699-2704

Markey B.K., Leonard F.C., Archambault M., Cullinane A. & Maguire D. 2013. Staphylococcus species. In Clinical veterinary microbiology, 2nd ed. P. 112. Edinburgh: Elsevier.

McCoy R.H. & Steenbergen F. 1969. Staphylococcus epizootic in western Oregon cottontails. Bulletin of the Wildlife Disease Association 5(1), 11. doi: 10.7589/0090-3558-5.1.11

Miller E.A., Goodman M. & Cox S., (eds.) 2017. Sulfamethoxazole (SMZ)/Trimethoprim (TMP). In NWRA Wildlife Formulary. 4th ed. P. 121. St. Cloud, MN: The National Wildlife Rehabilitators Association.

Ranzani O.T., Motos A., Chiurazzi C., Ceccato A., Rinaudo M., Bassi G.L., Ferrer M. & Torres A. 2020. Diagnostic accuracy of gram staining when predicting staphylococcal hospital-acquired pneumonia and ventilator-associated pneumonia: a systematic review and meta-analysis. Clinical Microbiology and Infection 26(11), 1456–1463. doi: 10.1016/j.cmi.2020.08.015

Schott R. 2017. Extra-label drug use in wildlife rehabilitation medicine. Wildlife Rehabilitation Bulletin 35(2), 33–36. doi: 10.53607/wrb.v35.20

Spaulding A.R., Satterwhite E.A., Lin Y.C., Chuang-Smith O.N., Frank K.L., Merriman J.A., Schaefers M.M., Yarwood J.M., Peterson M.L. & Schlievert P.M. 2012. Comparison of Staphylococcus aureus strains for ability to cause infective endocarditis and lethal sepsis in rabbits. Frontiers in Cellular and Infection Microbiology 2, 18. doi: 10.3389/fcimb.2012.00018

Stewart G.C. 2022. Staphylococcus. In D.S. McVey et al. (eds.): Veterinary microbiology. 4th ed. Pp. 231–239. Hoboken, NJ: Wiley-Blackwell. doi: 10.1002/9781119650836.ch25

Varga Smith M. 2023a. Infectious diseases of domestic rabbits. In Textbook of rabbit medicine. 3rd ed. Pp. 352–353. Edinburgh: Elsevier.

Varga Smith M. 2023b. Abscesses. In Textbook of rabbit medicine. 3rd ed. Pp. 224–225. Edinburgh: Elsevier.

Varga Smith M. 2023c. Therapeutics. In Textbook of rabbit medicine. 3rd ed. Pp. 100–137. Edinburgh: Elsevier.

Wardyn S., Kauffman L. & Smith T. 2012. Methicillin-resistant Staphylococcus aureus in Central Iowa Wildlife. Journal of Wildlife Diseases 48, 1069–1073. doi: 10.7589/2011-10-295

Published

2024-06-28

How to Cite

Paul, G. C., & Friend, D. G. (2024). Case report: disseminated Staphylococcus aureus infections in two infant desert cottontail rabbits (Sylvilagus audubonii). Wildlife Rehabilitation Bulletin, 42(1), 10–16. https://doi.org/10.53607/wrb.v42.273

Issue

Section

Case Studies

Categories